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These guidelines are intended to guide and facilitate the care of patients at Great Ormond Street Hospital for Children NHS Trust (GOSH). The guidance contained therein is not intended to replace individual assessment and personalised treatment of the patient. The authors attempt to base the guidance on best available evidence and ensure that content is up to date. The guidelines may not necessarily represent the views of all clinicians at GOSH. This information may be used for private education, research and institutional education but if used for any other purposes, consent must first be obtained from GOSH. Any person intending to use the guidelines should assess the suitability of use. GOSH will not accept any responsibility for use by external agencies or individuals. No part of this publication may be reproduced, stored in or introduced into a retrieval system or transmitted in any form without prior consent and acknowledgment of GOSH. GOSH retains copyright.

In some guidelines it is necessary to use product names to ensure clarity of information or for the purpose of identifying a specific type of product or drug. Where possible, generic product names have been used in preference to trade names or trade marks. Please be aware that use of any trade names listed in this document should not necessarily be seen as an endorsement of the product and that other similar products may be available.